Thanks to Muscle Memory, muscles have quick training response


I’m back on my workout schedule. I usually stop working out during the heart of Texas summers, from about mid-July and don’t start working out again until September 1. I have been feeling so bad however, I forced myself to start back early…

As in today.

I weighed myself in at 132 lbs. Ugh, no wonder I feel bad.

Time to take some of that summer weight off!

With that said, I must say this article (below) comes as wonderful news and very karmic that I should find it today. Hopefully this “muscle memory” will allow me to quickly get back into shape and then maybe I will STOP feeling so wore out.

Here’s to hoping anyway…

Pumping up is easier for people who have been buff before, and now scientists think they know why — muscles retain a memory of their former fitness even as they wither from lack of use.

That memory is stored as DNA-containing nuclei, which proliferate when a muscle is exercised. Contrary to previous thinking, those nuclei aren’t lost when muscles atrophy, researchers report online August 16 in the Proceedings of the National Academy of Sciences. The extra nuclei form a type of muscle memory that allows the muscle to bounce back quickly when retrained.


The findings suggest that exercise early in life could help fend off frailness in the elderly, and also raise questions about how long doping athletes should be banned from competition, says study leader Kristian Gundersen, a physiologist at the University of Oslo in Norway.

Muscle cells are huge, Gundersen says. And because the cells are so big, more than one nucleus is needed to supply the DNA templates for making large amounts of the proteins that give muscle its strength. Previous research has demonstrated that with exercise, muscle cells get even bigger by merging with stem cells called satellite cells, which are nestled between muscle fiber cells. Researchers had previously thought that when muscles atrophy, the extra nuclei are killed by a cell death program called apoptosis.

In the new study, Gundersen’s team simulated the effect of working out by making a muscle that helps lift the toes work harder in mice. As the muscle worked, the number of nuclei increased, starting on day six. Over the course of 21 days, the hard-working muscle increased the number of nuclei in each fiber cell by about 54 percent. Starting on day nine, the muscle cells also started to plump up, adding an extra 35 percent to their volume. Those results indicate that the nuclei come first and muscle mass is added later.


In another set of experiments, the researchers worked the mice’s muscles for two weeks and then severed nerves leading to the muscle so the tissue would atrophy. As the muscle atrophied, the cells deflated to about 40 percent of their bulked-up volume, but the number of nuclei in the cells did not change.

These results contradict previous studies that show lots of cell death in muscles during atrophy. Gunderson’s team examined individual cells in the wasting muscles and found that there is apoptosis going on, but that other cells are dying, not the muscle fibers or their extra nuclei. The extra nuclei stick around for at least three months — a long time for a mouse, which lives a couple of years on average, Gundersen says.

“I don’t know if it lasts forever,” he says, “but it seems to be a very long-lasting effect.” Since the extra nuclei don’t die, they could be poised to make muscle proteins again, providing a type of muscle memory, he says.


“That’s fascinating thinking, and there’s nice proof in this article to support it,” says Bengt Saltin, a muscle physiologist at the University of Copenhagen in Denmark. “It’s really novel and helps to explain descriptive findings that muscles are quick to respond upon further training.”

5 comments on “Thanks to Muscle Memory, muscles have quick training response

  1. In the summer most of us feel worn out. Too hot.
    It is known factor that people how were in shape most of their life stay ;longer in shape even if they dont train and it is easy to regain the previous muscles strength . Only thing i dont like to do is swimming .It doesn’t make me happy .Plus I had so many accident in the water that nope. i can sit in the pool and cool off but swimming is for fishes .
    You are 132 . I laughed at myself. I am happy around 142 . Big boned :)

    • I 5’3 so I have a tough time if I carry much more than that.

      And nope, not much on swimming myself but not so much because I don’t like it..I do. Mostly because I dislike what I KNOW is in the water. Ick. One of those instances where knowing too much is definitely NOT a good thing.

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